Table 4:
Stroke and Transient Ischemic Attack
| Author, Year N (TAVI/SAVR) | Any Stroke | Disabling Stroke | Nondisabling Stroke | Transient Ischemic Attack |
|---|---|---|---|---|
| 30 Days | ||||
| Mack et al, 201918 950 (496/454) PARTNER 3 |
KM estimate,a n (%) TAVI: 3 (0.6) SAVR: 11 (2.4) HR (95% CI) 0.25 (0.07–0.88) RD (95% CI)b −1.8% (−3.8% to 0.6%) |
KM estimate,a n (%) TAVI: 0 SAVR: 2 (0.4) HR cannot be calculated RD (95% CI)b −0.4% (−1.5% to 0.7%) |
KM estimate,a n (%) TAVI: 3 (0.6) SAVR: 9 (2.0) HR (95% CI) 0.30 (0.08–1.12) RD (95% CI)b −1.4% (−3.1% to 0.06%) |
KM estimate,a n (%) TAVI: 0 SAVR: 3 (0.7) HR cannot be calculated RD (95% CI)b −0.7% (−1.8% to 0.7%) |
| Popma et al, 201917 1,403 (725/678) Evolut LRT |
TAVI: 3.4% SAVR: 3.4% RD (95% BCrI) 0% (−1.9% to 1.9%) |
TAVI: 0.5% SAVR: 1.7% RD (95% BCrI) −1.2% (−2.4% to −0.2%) |
TAVI: 3.0% SAVR: 1.7% RD (95% BCrI) 1.2% (−0.3% to 2.9%) |
TAVI: 0.6% SAVR: 0.8% RD (95% BCrI) −0.2% (−1.2% to 0.7%) |
| 1–2 Years | ||||
| Mack et al, 201918 950 (496/454) PARTNER 3 |
KM estimatea, n (%) TAVI: 6 (1.2) SAVR: 14 (3.1) HR (95% CI) 0.38 (0.15–1.00) RD (95% CI)b −1.9% (−4.1% to 0.7%) |
KM estimatea, n (%) TAVI: 1 (0.2) SAVR: 4 (0.9) HR (95% CI) 0.22 (0.03–2.00) RD (95% CI)b −0.7% (−1.9% to 0.7%) |
KM estimatea, n (%) TAVI: 5 (1.0) SAVR: 10 (2.2) HR (95% CI) 0.45 (0.15–1.32) RD (95% CI)b −1.2% (−3.2% to 1.1%) |
KM estimatea, n (%) TAVI: 5 (1.0) SAVR: 5 (1.1) HR (95% CI) 0.89 (0.26–3.06) RD (95% CI)b −0.09% (−1.9% to 1.5%) |
| Popma et al, 201917 1,403 (725/678) Evolut LRT |
TAVI: 4.1% SAVR: 4.3% RD (95% BCrI) −0.2% (−2.4% to 1.9%) |
1 y TAVI: 0.8% SAVR: 2.4% RD (95% BCrI) −1.6% (−3.1% to −0.3%) 2 y TAVI: 1.1 SAVR: 3.5 RD (95% BCrI) −2.3% (−4.8% to −0.4%) |
TAVI: 3.4% SAVR: 2.2% RD (95% CI)b 1.1% (−0.6% to 2.9%) |
TAVI: 1.7% SAVR: 1.8% RD (95% CI)b −0.1% (−1.7% to 1.6%) |
Abbreviations: BCrI, Bayesian credible interval; CI, confidence interval; HR, hazard ratio; RD, risk difference; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve implantation.
a
Percentages provided are Kaplan-Meier estimates at the specific time point and do not necessarily equal number of patients who experienced the event divided by total number of patients in treatment group at the given time point.
b
Calculated by the authors of this report using the exact method.24