Figure 2.

Comparison of changes in detrusor metabolite levels involved in trans‐sulfuration pathways that would be expected to impact the methylation status of cells methylation pathways between (a) 3‐month diabetic versus non‐diabetic, age‐matched controls and (b) 3‐month diabetic, 1‐month insulin‐treated versus non‐diabetic, age‐matched controls. For each animal group metabolite levels were determined in N = 5 animals. The following color code was used for a difference in metabolite level compared to the non‐diabetic, age‐matched controls: red = fold‐change >1, p < .05; pink = fold‐change >1, p < .1; dark green = fold‐change <1, p < .05; black = no significant difference; grey = metabolite not detected. C) Average relative methylated cytosine in detrusor DNA compared to non‐diabetic, age‐matched controls (N = 3, * = significant decrease in methylated DNA relative to non‐diabetic, age‐matched controls, p‐value < 0.05)