Graphs show concentrations of sodium (A), potassium (B), chloride (C), bicarbonate (D), creatinine (E), and glucose (F). Lines denote means, and shaded bands denote 95% CIs. Plots were created with locally weighted scatterplot smoothing. Patients were censored at the time of hospital discharge or death. Separation of 95% CIs for chloride and bicarbonate suggest significant differences between the balanced crystalloids and saline groups. SI conversions: To convert bicarbonate to millimoles per liter, multiply by 1.0; chloride to millimoles per liter, multiply by 1.0; creatinine to micromoles per liter, multiply by 88.4; glucose to millimoles per liter, multiply by 0.0555; sodium to millimoles per liter, multiply by 1.0; potassium to millimoles per liter, multiply by 1.0.