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. 2020 Nov 16;10:19930. doi: 10.1038/s41598-020-76959-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes between fat-1 and WT control pair-fed animals. (a) Volcano plot analysis of significant genes from the fat-1 PF vs WT PF comparison. Genes are plotted as log₂(fold change) vs antilog(p-value). (b) GO Processes representative of decreased gene expression (green) and increased gene expression (red) for the fat-1 PF vs WT PF comparison. (c) Gene cluster analysis of genes decreased in fat-1 PF vs WT PF comparison (purple circles, green nodes). (d) Gene cluster analysis of genes increased in fat-1 PF vs WT PF comparison (yellow circles, copper nodes). Significant DEGs were selected based on a q-value < 0.05. Significant DEGs with fold-change greater than or equal to two-fold were used for analyses in (a–d). n = 3–5 mice per group.