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. 2020 Nov 16;10:19917. doi: 10.1038/s41598-020-77085-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolomic profiling of the CUMS rats receiving propionate administrations. (a) Principle component analysis (PCA) of the healthy control rats, the CUMS rats, and the CUMS rats receiving low/moderate/high-dose propionate. Red dots represent the healthy control group, green dots represent the CUMS group. Blue dots represent the group of CUMS rats receiving low-dose propionate. Black blocks represent the group of CUMS rats receiving moderate-dose propionate. Yellow stars represented the group of CUMS rats receiving high-dose propionate. Green arrows represented the trajectories of principle components. (b) S-plot analysis between the CUMS group and the CUMS + High-dose propionate group. (c) Score plot of Orthogonal Projection to Latent Structures Discriminant Analysis (OPLS-DA) between the CUMS group and the CUMS + High-dose propionate group.