Table 1.
Individual patient data
| Patient | Age years | Sex | Tumor site | Stage | Chemotherapy | RT dose Gy/fx | Salvage laryngectomy | Surgery/closure | Swallowing outcome | Time to dysphagia months | Follow-up months | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 62 | M | larynx | T2 N0 | no | 62/31 | yes | TL/no data | dysphagia | 4 | 22 | 3 primaries, NED |
| 2 | 58 | M | HP | T1 N3 | yes | 66/33 | yes | TL/no data | stenosis | 0 | 48 | NED |
| 3 | 55 | M | HP | T4 N1 | no | 66/33 | no | T/no | stenosis | 84 | 105 | NED, CLL, melanoma |
| 4 | 59 | F | larynx | T2 N1 | no | 66/33 | yes | T/PC fistula | normal | NA | 12 | NED after 3 primaries |
| 5 | 54 | M | larynx | T3 N0 | no | 60/30 | no | TL/no | normal | NA | 96 | NED |
| 6 | 56 | M | larynx | T4 N0 | no | 60/30 | no | TL/no | normal | NA | 90 | NED |
| 7 | 62 | F | HP | T3 N1 | no | 60/30 | no | TL/no | normal | NA | 85 | NED |
| 8 | 74 | M | larynx | T4 N0 | no | 60/30 | no | TL/no | normal | NA | 84 | NED, prostate cancer |
| 9 | 73 | M | larynx | T2 N0 | no | 64/32 | no | TL/no | normal | NA | 84 | NED |
| 10 | 53 | F | larynx | T3 N0 | no | 60/30 | no | vert./no | normal | NA | 87 | NED |
| 11 | 53 | M | larynx | T4 N2b | no | 70/35 | yes | vert./no | stenosis | 0 | 62 | died |
| 13 | 58 | M | larynx | T3 N0 | no | 60/30 | no | T/no | dysphagia | 30 | 36 | NED, lost to FU |
| 14 | 67 | M | larynx | T3 N2b | no | 60/30 | no | T/no | normal | NA | 1 | died |
| 15 | 55 | M | larynx | T4 N2c | no | 60/30 | no | vert./no data | normal | NA | 48 | NED |
| 16 | 67 | M | larynx | T3 N0 | no | 60/30 | no | TL/no data | stenosis | 18 | 54 | NED |
| 17 | 54 | M | larynx | T3 N2b | yes | 70/35 | yes | TL/PC fistula | stenosis | 6 | 42 | NED, lost to FU |
| 18 | 50 | M | HP | T2 N3 | no | 60/30 | no | TL-PMC/no | stenosis | 2 | 51 | NED |
| 19 | 54 | M | HP | T2 N2b | no | 64/32 | no | TL/no data | dysphagia | 5 | 28 | died |
| 20 | 75 | F | larynx | T2 N1 | no | 64/32 | no | T/no | stenosis | 18 | 42 | NED |
| 21 | 57 | M | larynx | T2 N1 | no | 70/35 | yes | TL/no data | dysphagia | 6 | 6 | NED |
| 22 | 45 | M | larynx | T3 N3 | no | 61.2/34 | no | TL/no data | normal | NA | 31 | NED |
| 23 | 72 | M | larynx | T4 N2c | no | 60/30 | no | TL/no | normal | NA | 0.3 | died 11 days after RT |
| 24 | 48 | M | larynx | T3 N2c | no | 66/33 | no | TL/no | normal | NA | 6 | NED, lost to FU |
| 25 | 56 | M | larynx | T4 N2b | no | 66/33 | no | TL/no | normal | NA | 26 | lung and bone metastases |
| 26 | 56 | M | larynx | T3 N0 | no | 56/28 | no | TL/no | dysphagia | 12 | 21 | lung metastasis |
| 27 | 49 | M | larynx | T3 N0 | no | 54/27 | no | TL/no | normal | 1.5 | 18 | recurrent cancer |
| 30 | 52 | M | larynx | T4 N0 | no | 66/33 | no | vert./no | normal | NA | 12 | NED |
| 31 | 59 | F | larynx | T4 N2c | no | 60/30 | no | T/no | stenosis | 3 | 15 | NED |
| 32 | 54 | M | larynx | T4 N2c | yes | 70/35 | yes | TL-PMC/no | normal | 0 | 6 | NED |
| 33 | 67 | M | larynx | T4 N2c | no | 60/30 | no | TL/no | normal | NA | 9 | NED |
fx = fractions; NED = no evidence of disease; HP = hypopharynx; T = T closure; CLL = chronic myelogenous leukemia; PC = pharyngocutaneous; NA = not assessed; vert. = vertical closure; FU = follow-up; PMC = pectoralis myocutaneous flap.