Table 4.

CMB Counts and CMB Volume Ratios in 14 Brain Regions

Brain Regions	CMB Count, Median (Range)			CMB Volume Ratio, Median (Range), %
Brain Regions	Preclinical Stage (n=10)	Duration <5 y (n=22)	Duration ≥5 y (n=17)	Preclinical Stage (n=10)	Duration <5 y (n=22)	Duration ≥5 y (n=17)
Frontal^a	0 (0–0)	0.5 (0–25)	2 (0–64)	0.00 (0.00–0.00)	0.00 (0.00–0.19)	0.02 (0.00–0.47)
Parietal	0 (0–0)	0.5 (0–12)	1 (0–35)	0.00 (0.00–0.00)	0.01 (0.00–0.30)	0.03 (0.00–0.77)
Temporal^a	0 (0–1)	2 (0–46)	5 (0–67)	0.00 (0.00–0.01)	0.03 (0.00–0.72)	0.08 (0.00–1.03)
Limbic	0 (0–1)	1 (0–20)	2 (0–31)	0.00 (0.00–0.02)	0.03 (0.00–0.56)	0.06 (0.00–0.70)
Occipital	0 (0–1)	0 (0–23)	1 (0–31)	0.00 (0.00–0.02)	0.00 (0.00–0.65)	0.02 (0.00–0.63)
Caudate	0 (0–0)	0 (0–8)	1 (0–4)	0.00 (0.00–0.00)	0.00 (0.00–1.85)	0.05 (0.00–2.35)
Putamen	0 (0–2)	0 (0–17)	1 (0–18)	0.00 (0.00–0.73)	0.00 (0.00–3.45)	0.21 (0.00–5.30)
Globus pallidum	0 (0–0)	0 (0–8)	0 (0–3)	0.00 (0.00–0.00)	0.00 (0.00–4.66)	0.01 (0.00–2.56)
Thalamus^a ^, ^b	0 (0–2)	2 (0–32)	12 (0–56)	0.00 (0.00–1.04)	0.44 (0.00–6.39)	1.91 (0.00–12.35)
Corpus callosum	0 (0–0)	0 (0–0)	0 (0–1)	0.00 (0.00–0.00)	0.00 (0.00–0.00)	0.00 (0.00–0.11)
Midbrain	0 (0–0)	0 (0–2)	0 (0–3)	0.00 (0.00–0.01)	0.00 (0.00–1.30)	0.02 (0.00–2.99)
Pons	0 (0–0)	0 (0–13)	2 (0–16)	0.00 (0.00–0.00)	0.00 (0.00–4.31)	0.46 (0.00–7.79)
Medulla	0 (0–0)	0 (0–7)	0 (0–9)	0.00 (0.00–0.00)	0.00 (0.00–3.28)	0.00 (0.00–5.95)
Cerebellum	0 (0–2)	0 (0–21)	0 (0–23)	0.00 (0.00–0.02)	0.00 (0.00–0.72)	0.01 (0.00–1.15)

CMB indicates cerebral microbleed.

CMB counts in the frontal lobe, temporal lobe, and thalamus increased more rapidly as disease advanced, with a significant interaction effect between CMB counts and disease stages in the linear mixed models (P<0.05).

CMB volume ratio in the thalamus increased more rapidly as disease advanced, with a significant interaction effect between CMB volume ratio and disease stages in the linear mixed models (P<0.05).