Table 5.

Associations Between CMB Burdens in Different Brain Regions and Mini‐Mental State Examination Scores

Brain Region	CMB Count		CMB Volume Ratio, %
	β (95% CI)	P Valuea	β (95% CI)	P Valuea
Whole brain	−0.05 (−0.07 to −0.02)	1.0×10−3 b	−58.86 (−93.83 to −23.89)	1.5×10−3 b
Frontal	−0.31 (−0.46 to −0.16)	1.2×10−4 b	−41.25 (−60.67 to −21.84)	9.9×10−5 b
Parietal	−0.34 (−0.58 to −0.11)	0.005	−15.29 (−25.83 to −4.75)	0.005
Temporal	−0.19 (−0.32 to −0.07)	3.1×10−3 b	−12.79 (−20.46 to −5.12)	1.6×10−3 b
Limbic	−0.26 (−0.54 to 0.02)	0.070	−10.63 (−20.53 to −0.74)	0.036
Occipital	−0.32 (−0.61 to −0.40)	0.026	−15.72 (−27.12 to −4.31)	0.008
Caudate	−0.83 (−2.09 to 0.43)	0.192	−3.22 (−7.17 to − 0.74)	0.108
Putamen	−0.42 (−0.85 to 0.01)	0.058	−1.53 (−3.35 to 0.29)	0.098
Globus pallidum	−0.78 (−2.29 to 0.73)	0.304	−1.79 (−4.19 to 0.61)	0.139
Thalamus	−0.16 (−0.31 to −0.00)	0.046	−0.60 (−1.25 to 0.04)	0.066
Corpus callosum	1.14 (−8.22 to 10.50)	0.808	11.42 (−102.72 to 125.55)	0.841
Midbrain	−1.62 (−4.71 to 1.47)	0.295	− 3.08 (−6.83 to 0.67)	0.105
Pons	−0.97 (−1.42 to −0.52)	7.5×10−5 b	−2.61 (−3.67 to −1.56)	9.8×10−6 b
Medulla	−1.07 (−1.99 to −0.14)	0.025	−1.89 (−3.56 to −0.22)	0.028
Cerebellum	−0.38 (−0.77 to 0.01)	0.056	−10.12 (−19.36 to −0.87)	0.033

CMB indicates cerebral microbleed.

^a P value was obtained from multivariate linear regression with adjustment of age, sex, and education years.

^bTo eliminate the concern of multiple testing, a 2‐sided P<0.00357 (0.05/14) was considered statistically significant.