TABLE 3.

Baseline protein levels of the most important molecules involved in the regeneration process and doses employed to obtain a favorable regenerative environment.

Nt Factor	Baseline protein levels	Experimental doses
		Mixed nerves	Sensory nerves	Motor nerves
Preclinical trials
NGF	211 pg/mg [Grosheva et al., 2016] 130 pg/mL [Shakhbazau et al., 2012]	0.8–1 μg/mL [Kemp et al., 2011; Santos et al., 2016a] 0.5 μg/mL [Chang et al., 2017; Li et al., 2018]	1 μg/mL [Kemp et al., 2011; Santos et al., 2016a] 20 μg/mL [Anand et al., 2017]
BDNF	5 pg/mg [Grosheva et al., 2016] 14.8 pg/mL [Omura et al., 2005; Shakhbazau et al., 2012; Shakhbazau et al., 2012]	10 μg/mL [Kemp et al., 2011; Santos et al., 2016a] 10–100 μg/mL [Chang et al., 2017]		2 μg/mL [Kemp et al., 2011; Santos et al., 2016a] 20 μg/mL [Anand et al., 2017]
NT3	6 pg/mL [Shakhbazau et al., 2012] 100 pg/mg [Omura et al., 2005; Shakhbazau et al., 2012]	2 μg/mL [Kemp et al., 2011; Santos et al., 2016a]	1 μg/mL [Glazner et al., 1993]	0.5 μg/mL [Sterne et al., 1997]
GDNF	150 pg/mL [Shakhbazau et al., 2012]	20 μg/mL [Alsmadi et al., 2018]	20 μg/mL [Anand et al., 2017]	20 μg/mL [Anand et al., 2017]
IGF1	793 pg/mg [Grosheva et al., 2016]	50–100 μg/mL [Sullivan et al., 2008]	100 μg/mL [Apel et al., 2010]	100 μg/mL [Apel et al., 2010]
IGF2	39 pg/mg [Grosheva et al., 2016]	1 μg/mL [Caplan et al., 1999]	1 μg/mL [Glazner et al., 1993]	0.05 μg/mL [Near et al., 1992]
FGF	45 pg/mg [Grosheva et al., 2016]	0.025–0.5 μg/mL [Kemp et al., 2011; Santos et al., 2016a] 0.5 μg/mL [Li et al., 2018]	10 μg/mL [Lee et al., 2017]	100 μg/mL [Guzen et al., 2016]
CNTF	100 ng/mg [Grosheva et al., 2016]	300 μg/mL [Newman et al., 1996]	50 μg/mL [Dubový et al., 2011]
PTN	20.2–24 pg/mL [Höke et al., 2006]	20 μg/mL [Alsmadi et al., 2018]	20 μg/mL [Anand et al., 2017]	0.1 μg/mL [Mi et al., 2007]
Clinical trials
NGF	0.1 μg/kg [Apfel, 2002; Apfel, 2002; Li et al., 2020]
FGF	2 ml [Apfel, 2002; Wu et al., 2011; Li et al., 2020]

The reference articles for this value are in square brackets.