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. Author manuscript; available in PMC: 2020 Nov 17.
Published in final edited form as: Int J Biochem Cell Biol. 2014 Apr 12;51:111–119. doi: 10.1016/j.biocel.2014.03.026

Fig. 1.

Fig. 1.

The chemical structure of linsitinib and the effect of linsitinib on the cell lines used in the study. (A) The chemical structure of linsitinib (cis-3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol). (B) Cytotoxicity of linsitinib in HEK293/pcDNA3.1, ABCG2-482-R2, ABCG2-482-G2 and ABCG2-482-T7 cell lines. (C) Cytotoxicity of linsitinib in H460 and H460/MX20 cell lines. (D) Cytotoxicity of linsitinib in HEK293/pcDNA3.1 and HEK293/ABCC10 cell lines. (E) Cytotoxicity of linsitinib in SW620 and SW620/AD300 cell lines. (F) Cytotoxicity of linsitinib in HEK293/pcDNA3.1 and HEK293/ABCC1 cell lines.