Table 1.
Description of the nine risk factors with available genetic data from GWAS
| Risk factor (units) | Number* of SNPs | GWAS Catalog accession number | Study reference | Sample size | Population |
|---|---|---|---|---|---|
| Alcohol consumption (drinks per week)† | 98 | GCST007472 | Liu et al. [24] | 1,039,210 | 100% European |
| Body mass index (adult, kg/m2) | 100 | GCST006368 | Hoffmann et al. [25] | 334,487 | 81% European |
| Height (adult, m) | 112 | GCST002647 | Wood et al. [26] | 253,288 | 100% European |
| Mammographic density (dense vs non-dense area) | 5 | GCST002667 | Lindström et al. [27] | 16,015** | 100% European |
| Menarche (age at onset) | 82 | GCST002541 | Perry et al. [28] | 182,413** | 100% European |
| Menopause (age at onset) | 34 | GCST005312 | Day et al. [29] | 69,626** | 100% European |
| Physical activity (overall physical activity time) | 3 | GCST006912 | Doherty et al. [30] | 91,105 | 100% European |
| Smoking behaviour (ever vs never)‡ | 119 | GCST007327 | Karlsson Linnér et al. [31] | 518,633 | 100% European |
| Type 2 diabetes mellitus (yes vs no) | 95 | GCST006867 | Xue et al. [32] | 659,316 (62,892 cases and 596,424 controls) | 99% European |
*The number of SNPs here may be lower than in the GWAS due to filtering (see the “Methods” section)
**Partial overlap with samples from BCAC
†Defined as the average number of drinks a participant reported drinking each week, aggregated across all types of alcohol
‡This is a binary phenotype. Participants who reported ever being a regular smoker in their life (current or former) were coded “2”, while participants who reported never being a regular smoker in their life were coded “1”