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. 2020 Nov 17;39:246. doi: 10.1186/s13046-020-01758-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The effects of circMCTP2 can be reversed by the knockdown of MTMR3. a The expression levels of MTMR3 in BGC823CDDP and SGC7901CDDP cells after transfection with lentivirus-shMTMR3 were determined by qRT-PCR. b Protein expression levels of MTMR3 in BGC823CDDP and SGC7901CDDP cells were detected by western blotting. c and d Effects of circMCTP2 on cell proliferation and colony formation by BGC823CDDP cells were reversed by the knockdown of MTMR3. e and f Decreased cell proliferation and colony-forming ability of SGC7901CDDP cells caused by circMCTP2 were restored by the knockdown of MTMR3. g MTMR3 knockdown reversed the effects of circMCTP2 on cell viability. h Expression levels of apoptotic proteins were examined by western blotting. i and j Flow cytometric analysis was performed to determine whether shMTMR3 could reverse the effect of circMCTP2 on the apoptosis of BGC823CDDP and SGC7901CDDP cells. CDDP treatment: 12 μM for 48 h in BGC823CDDP cells and 6 μM for 48 h in SGC7901CDDP cells. (*p < 0.05, **p < 0.01. Data are expressed as the means ± SDs)