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. 2020 Aug 28;41(18):5141–5150. doi: 10.1002/hbm.25180

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© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Apolipoprotein E (APOE) genotype interactions. Left plot: The lines show the association (β) between age started hormone replacement therapy (HRT) and apparent brain aging for the APOE e4 carriers (red) and non‐carriers (blue). The fitted values are corrected for the covariates in the model (age, number of births, had hysterectomy, and/or oophorectomy). Right plot: The lines show the association between estradiol levels and apparent brain aging for the APOE e4 carriers (red) and non‐carriers (blue). The fitted values are corrected for the covariates in the model (age, number of births, current HRT use, ever used HRT, length since menopause, age at first birth, and education). The shaded areas show the 68.3% (1 SD) and 95% (2 SD) confidence intervals for each fit