TABLE 5.
The associations between each estimate of sex‐hormone exposure and apparent brain aging
| variable | β | SE | t | p | pcorr |
|---|---|---|---|---|---|
| ICEE | 0.040 | 0.014 | 2.809 | .005 | .018* |
| HRT status | 0.169 | 0.055 | 3.073 | .002 | .015* |
| Age at HRT initiation | 0.022 | 0.009 | 2.509 | .012 | .028* |
| Duration of HRT usage | 0.004 | 0.005 | 0.787 | .432 | .503 |
| OC status | 0.017 | 0.066 | 0.250 | .802 | .802 |
Note: β, slope; ICEE, Index of cumulative estrogen exposure. Hormone replacement therapy (HRT) and oral contraceptive (OC) status = 0 for never‐users and 1 for current and former users. Each analysis included age and number of births as a covariates, in addition to specific covariates for each measure as detailed in Section 3. p values are reported before and after false discovery rate (FDR)‐correction (pcorr) (Benjamini & Hochberg, 1995). Corrected p values below 0.05 are marked with an asterisk.