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Plasma concentration vs. time profiles of (a) imatinib; in the control (imatinib only) group, imatinib+ l-GS group, and imatinib+ h-GS group, in closed circles, squares, and diamonds, respectively. b N-desmethyl imatinib; in the control (imatinib only) group, imatinib+ l-GS group, and imatinib+ h-GS group, in open-crossed circles, squares, and diamonds, respectively. Data: mean ± SE (n = 5–6). l-GS and h-GS: low and high dose of grape seed extract, respectively
