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. 2020 Nov 16;17:342. doi: 10.1186/s12974-020-02023-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effect of SIS3 and LPS on nigrostriatal dopaminergic system in rats. a Representative figures of TH expression (immunohistochemistry) in the SN and striatum. Scale bar = 200 μm in the SN (upper panels); 50 μm in the SN (below panels); and 500 μm in the striatum. b Quantification of TH⁺ neuron number in the SN is shown. c Quantification of TH⁺ innervations in the striatum is shown. d Protein level of TH in the SN was detected by western blotting and its quantitative analysis. e Protein level of TH in the striatum was detected by western blotting and its quantitative analysis. The results are expressed as mean ± SEM. N = 6. *p < 0.05, compared with the rats treated with vehicle; #p < 0.01, compared with the rats treated with vehicle; ▽p < 0.01, compared with the rats treated with vehicle or LPS; ▲p < 0.05, compared with the rats treated with vehicle, SIS3, or LPS; ▼p < 0.01, compared with the rats treated with vehicle, SIS3, or LPS. LPS, lipopolysaccharide (1 mg/kg); SIS3 (4 μg/each side)