Table 2.

List of proteins with altered expression in COPD patients vs the controls, as per the MALDI sequencing analysis

S. No.	Name of the identified proteins	Fold change	Predicted function
1	Preg. Zone Protein (PZP)	−3.6	Protease inhibitor, able to inhibit all four classes of proteases
2	α-2 Macroglobulin(A2MG)	−2.5	Protease inhibitor, able to inhibit all four classes of proteases
3	Peptidase Inhibitor (PI16)	−2.3	Serine Protease Inhibitor
4	Serotransferrin TRFE_Human)	−2.0	To prevent oxidative damage
5	Cytokine suppressor (SOCS-3)	3.1	SOCS-3; Suppressor of cytokine signaling. SOCS3 involved in the negative regulation of cytokines.
6	Carboxy peptidase B2,(CBPB2)	2.4	Carboxy peptidase (cleave basic amino residues), plays a major role in the breakdown of the extracellular matrix
7	Matrix Metallo Protease −2 (MMP-II)	2.6	MMP-2 or Gelatinase A or type IV Collagenase, breakdown extracellular matrix
8	Human Leukocyte Elastase (HLE)	2.8	Serine Protease that hydrolyzes many proteins in addition to Elastin