. 2020 Nov 17;20:1115. doi: 10.1186/s12885-020-07591-w

Table 2.

Target volume definitions

Target volume	Definition	MSKCC Standard Approach
GTV	Gross tumor in the bone, including soft tissue extension	Consider fusing diagnostic imaging including PET. MRI is recommended for spinal metastases. Consider reviewing diagnostic and/or simulation imaging with a diagnostic radiologist.
CTV	Margin for microscopic extension of tumor	GTV + 5 mm but not extending beyond the bone unless direct extension with adjacent tissue invasion is present. NOTE: For lesions in the spine undergoing SBRT, published guidelines will be followed [24]
PTV	Margin for setup error (patient positioning and treatment delivery)	CTV + 3 mm (if using daily CBCT)

Target volume

Definition

MSKCC Standard Approach

GTV

Gross tumor in the bone, including soft tissue extension

Consider fusing diagnostic imaging including PET. MRI is recommended for spinal metastases.

Consider reviewing diagnostic and/or simulation imaging with a diagnostic radiologist.

CTV

Margin for microscopic extension of tumor

GTV + 5 mm but not extending beyond the bone unless direct extension with adjacent tissue invasion is present.

NOTE: For lesions in the spine undergoing SBRT, published guidelines will be followed [24]

PTV

Margin for setup error (patient positioning and treatment delivery)

CTV + 3 mm (if using daily CBCT)