Table 3.
Association analysis of individual SNPs and genotypes in the CHRM2 gene in cases and healthy controls
| SNP |
n (%) |
OR [95 % CI] | P | ||
|---|---|---|---|---|---|
| Healthy controls N = 450 | Asthmatic cases N = 398 | ||||
| rs978437 | GG | 217 (48) | 171 (43) | ||
| GA | 193 (43) | 170 (43) | |||
| AA | 40 (9) | 57 (14) | |||
| G | 627 (70) | 512 (64) | |||
| A | 273 (30) | 284 (36) | 1.27 [1.04–1.56] | 0.019 | |
| GG vs AA | 1.81 [1.15–2.84] | 0.009 | |||
| rs1455858 | AA | 216 (48) | 166 (42) | ||
| AG | 193 (43) | 177 (44) | |||
| GG | 40 (9) | 55 (14) | |||
| A | 625 (70) | 509 (64) | |||
| G | 273 (30) | 287 (36) | 1.29 [1.06–1.58] | 0.013 | |
| AA vs GG | 1.79 [1.13–2.82] | 0.011 | |||
| rs1824024 | GG | 216 (48) | 173 (44) | ||
| GT | 194 (43) | 173 (44) | |||
| TT | 39 (9) | 52 (14) | |||
| G | 626 (70) | 517 (65) | |||
| T | 272 (30) | 279 (35) | 1.23 [1.01–1.51] | 0.048 | |
| GG vs TT | 1.66 [1.05–2.64] | 0.029 | |||
| rs324640 | GG | 284 (63) | 228 (57) | ||
| GA | 144 (32) | 142 (36) | |||
| AA | 22 (5) | 28 (7) | |||
| G | 712 (79) | 595 (75) | |||
| A | 188 (21) | 199 (25) | 1.25 [1.0–1.57] | 0.051 | |
| rs324650 | AA | 274 (61) | 218 (55) | ||
| AT | 149 (33) | 151 (38) | |||
| TT | 27 (6) | 29 (7) | |||
| A | 697 (77) | 589 (74) | |||
| T | 203 (23) | 207 (26) | 1.22 [0.98–1.53] | 0.076 | |
| rs8191992 | AA | 275 (61) | 199 (50) | ||
| AT | 148 (33) | 165 (42) | |||
| TT | 27 (6) | 32 (8) | |||
| A | 698 (78) | 563 (71) | |||
| T | 202 (22) | 229 (29) | 1.42 [1.14–1.77] | 0.001* | |
| AA vs AT | 1.55 [1.16–2.06] | 0.003 | |||
| AA vs (AT+TT) | 1.57 [1.20–2.06] | 0.0001 | |||
| rs6962027 | AA | 278 (62) | 194 (49) | ||
| AT | 145 (32) | 170 (43) | |||
| TT | 27 (6) | 34 (8) | |||
| A | 701 (78) | 558 (70) | |||
| T | 199 (22) | 238 (30) | 1.50 [1.21–1.87] | 0.0002* | |
| AT vs AT | 1.68 [1.26–2.24] | 0.0004 | |||
| AA vs TT | 1.80 [1.05–3.09] | 0.0296 | |||
| AA vs (AT+TT) | 1.67 [1.25–2.22] | 0.0001 | |||
*
Significant P values were observed after 100,000 permutations (P = 0.003 and 0.005, respectively). Only statistical significant data from genotype comparison are showed