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. 2020 Nov 17;28(6):867–879.e5. doi: 10.1016/j.chom.2020.11.004

Figure 3.

Figure 3

Cryo-EM Analyses Reveal Lower pH to Reduce Spike-Conformational Heterogeneity Culminating in an All RBD-Down Conformation at pH 4.0

(A) Structures at pH 5.5 with particle prevalence and resolution of determined structures.

(B) Structure of spike at pH 4.5.

(C) Structure of spike at pH 4.0.

(D) Example of reconstruction density. A region at the central helices of the pH 4.0 structure is shown with well-defined water molecules. The contour level is 0.015 (5.7 σ).

See also Figure S4, Tables S2 and S3, and Videos S1, S2, S3, and S4.