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. Author manuscript; available in PMC: 2020 Nov 17.
Published in final edited form as: AAPS J. 2019 Jul 11;21(5):87. doi: 10.1208/s12248-019-0358-2

Figure 3: Volcano plot of FPOP comparison of adalimumab biosimilar in 50 mM sodium phosphate buffer, 0.1% polysorbate-80 (pH 6.0) after dosimetry-based compensation versus 50 mM sodium phosphate buffer (pH 6.0) as a reference.

Figure 3:

FPOP was performed with 15% exclusion volume, 100 mM H2O2, in 100 μm ID capillary, with the radical dosage altered to generate equivalent adenine dosimetry readings. Each point represents one peptide from the biosimilar, with the X-axis representing the fold change in oxidation amount in citrate buffer as compared to phosphate buffer, and the Y-axis representing the p-value from a two-tailed Student’s t-test. The four shaded regions represent statistically significant changes in oxidation (α = 0.05).