Figure 1.

Cell populations identified in critically ill COVID-19 patients. Panel A. depicts the t-SNE from COVID-19 critically ill patients scRNAseq data. Twelve clusters are represented by immature myeloid populations such as band neutrophils, metamyelocytes, promyelocytes-myelocytes, monocytoid precursor, immature monocytes. Mature lineages such as segmented neutrophils, mature monocytes and finally monocyte-macrophages are observed. Scarce lymphoid cell populations, represented by B, T and NK cells are present in these patients. In contrast, panel B. shows the t-SNE from scRNAseq data from healthy donors with lymphoid T, Th1, NK and B cells predominance compared to monocytes.