Table 1.
Subject demographics and baseline characteristics by age
| All subjects | <65 years | ≥65 years | |||||||
| Sema 0.5 mg |
Dula 0.75 mg |
Sema 1.0 mg |
Dula 1.5 mg |
Sema 0.5 mg |
Dula 0.75 mg |
Sema 1.0 mg |
Dula 1.5 mg |
||
| n | 1199 | 222 | 238 | 247 | 232 | 79 | 61 | 53 | 67 |
| Age, years | 56 (10.6) | 51.6 (8.4) | 51.7 (8.3) | 52.4 (9.0) | 52.0 (8.5) | 69.4 (4.4) | 69.1 (3.9) | 69.3 (4.2) | 69.4 (3.9) |
| Sex, n (%) | |||||||||
| Male | 662 (55.2) | 119 (53.6) | 131 (55.0) | 132 (53.4) | 130 (56.0) | 50 (63.3) | 29 (47.5) | 30 (56.6) | 41 (61.2) |
| Female | 537 (44.8) | 103 (46.4) | 107 (45.0) | 115 (46.6) | 102 (44.0) | 29 (36.7) | 32 (52.5) | 23 (43.4) | 26 (38.8) |
| Diabetes duration, years | 7.4 (5.7) | 6.8 (5.4) | 6.3 (5.2) | 6.6 (5.3) | 6.9 (5.2) | 10.2 (6.7) | 9.8 (5.9) | 10.2 (6.6) | 10.3 (6.3) |
| HbA1c, % | 8.2 (0.9) | 8.4 (1.0) | 8.2 (0.9) | 8.3 (0.9) | 8.3 (0.9) | 8.1 (0.9) | 8.0 (0.8) | 7.9 (0.8) | 8.0 (0.8) |
| HbA1c, mmol/mol | 66.4 (10.0) | 68.2 (10.7) | 66.2 (10.1) | 66.9 (10.1) | 66.7 (9.9) | 65.4 (9.7) | 63.6 (9.0) | 62.8 (9.2) | 64.1 (8.7) |
| Body weight, kg | 95.2 (22.6) | 97.8 (25.6) | 96.5 (23.6) | 97.2 (20.7) | 94.3 (23.2) | 92.4 (20.1) | 92.1 (20.4) | 87.4 (20.2) | 90.2 (15.8) |
| BMI, kg/m2 | 33.5 (6.8) | 34.4 (7.7) | 34.0 (7.1) | 34.2 (6.6) | 33.4 (6.9) | 31.7 (4.5) | 32.4 (5.9) | 30.9 (5.1) | 32.1 (5.4) |
| Race, n (%) | |||||||||
| Asian | 191 (15.9) | 44 (19.8) | 45 (18.9) | 34 (13.8) | 52 (22.4) | 6 (7.6) | 3 (4.9) | 4 (7.5) | 3 (4.5) |
| Black/African American | 70 (5.8) | 13 (5.9) | 13 (5.5) | 14 (5.7) | 16 (6.9) | 4 (5.1) | 4 (6.6) | 4 (7.5) | 2 (3.0) |
| White | 928 (77.4) | 164 (73.9) | 178 (74.8) | 198 (80.2) | 158 (68.1) | 69 (87.3) | 54 (88.5) | 45 (84.9) | 62 (92.5) |
| Other | 10 (0.8) | 1 (0.5) | 2 (0.8) | 1 (0.4) | 6 (2.6) | 0 | 0 | 0 | 0 |
| Ethnic group, n (%) | |||||||||
| Hispanic/Latino | 138 (11.5) | 23 (10.4) | 30 (12.6) | 30 (12.1) | 38 (16.4) | 6 (7.6) | 1 (1.6) | 5 (9.4) | 5 (7.5) |
| Non-Hispanic/Latino | 1061 (88.5) | 199 (89.6) | 208 (87.4) | 217 (87.9) | 194 (83.6) | 73 (92.4) | 60 (98.4) | 48 (90.6) | 62 (92.5) |
‘On-treatment without rescue medication’ data. Subgroup data are presented as mean (SD) unless otherwise indicated.
n: number of subjects randomised and exposed to at least one dose of trial product as randomised (full analysis set).
BMI, body mass index; Dula, dulaglutide; HbA1c, glycated haemoglobin; Sema, semaglutide.