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Sequence entropy in naïve human antibodies and human germlines
(a). Sequence entropy for 12 common germlines in a naive human antibody sample (>10,000 sequences for each germline). (b). Sequence entropy for human germlines derived from all IGKV, IGLV, and IGHV sequences from IMGT. From left to right, the pink shaded regions indicate CDR1, CDR2, and the DE loop. CDR3 is omitted due to varying lengths and different diversification mechanisms.
