Table 2.

DE loop canonical families

Gene	Cluster	Rama. string	Common sequence	# PDB chains (all)	# PDB chains (≥0.75 EDIA)	% chains (all)	% chains (≥0.75 EDIA)	Unique seqs (all)	Unique seqs (≥0.75 EDIA)	1	2	3	4	5	6	7	8
κ	L4-6-1	EBEABB	GSGTDF	3,854	1,393	64.5	66.6	77	48	120, 170	−164, 158	73, −100	−118, −11	−119, 122	−132, 153
λ/κ*	L4-6-2	BBEABB	KSGTTA	1,377	562	23.0	26.9	81	67	−141, 136	−144, 114	64, −120	−100, 10	−120, 136	−115, 148
κ	L4-6-3	BBAABB	GSGTDF	95	48	1.6	2.3	7	4	163, 168	−90, −144	−88, −23	−128, −13	−125, 125	−131, 151
λ	L4-6-4	BBLLBB	LIGGKA	31	14	0.5	0.7	6	5	−110, 130	−138, 123	51, 48	70, 12	−124, 156	−86, 145
λ/κ	noise	-	-	622	76	10.4	3.5	74	29	-	-	-	-	-	-
λ5/λ6	L4-8-1	BBAAALBB	IDSSSNSA	90	40	100.0	100.0	8	6	−128, 135	−120, 100	−65, −31	−66, −34	−101, 2	54, 44	−134, 156	−111, 151
H	H4-6-1	BBAABB	RTSTTV	35	21	76.1	100.0	4	3	−134, 152	−119, −172	−64, −34	−124, 0	−138, 158	−127, 133
H	noise	-	-	11	0	23.9	0.0	5	0	-	-	-	-	-	-	-	-
H	H4-7-1	BABAABB		37	17	100.0	100.0	7	4	−94, 112	−90, −22	−160, −176	−71, −15	−125, 5	−135, 137	−124, 140
H	H4-8-1	BBAAALBB	RDNSKNTA	6,269	1,953	94.0	96.8	646	333	−143, 149	−122, 110	−65, −30	−67, −34	−102, 2	53, 47	−129, 141	−113, 144
H	H4-8-2	BBAALABB	RDNSKSTA	60	19	0.9	1.1	26	12	−136, 155	−80, 169	−60, −39	−72, −12	64, 28	−104, −11	−135, 137	−115, 145
H	noise	-	-	347	37	5.1	2.1	121	13	-	-	-	-	-	-	-	-

Properties and frequencies of L4 and H4 structural clusters and noise structures for each length of light chain and heavy chain DE loop. The clustering was performed on the entire PDB and on a subset of structures that pass an electron density cutoff (EDIA≥0.75). ϕ,ψ values (in degrees) are given for each residue in each cluster of L4-6, L4-8, H4-6, H4-7, and H4-8 DE loop length families. Ramachandran map regions are: A = alpha-helix region; B = beta sheet region; E = epsilon region (lower right of Ramachandran map); L = alpha-left region.

* Cluster L4-6-2 is composed of 75% λ chains and 25% κ chains