(Petrovic et al. 2002) |
Placebo analgesia |
PET rCBF |
Thermal |
9 |
N/A |
1. (Pain + Placebo)-(Pain alone); 2.[(Pain + Placebo)-(Pain alone)]-[(Warm + Placebo)-(Warm alone]) |
(Wager et al. 2004): Study 1 |
Placebo analgesia |
fMRI |
Shock |
24 |
1. (Control-Placebo)-(Intense-Mild Shock) |
N/A |
(Wager et al. 2004): Study 2 |
Placebo analgesia |
fMRI |
Thermal |
23 |
1. (Control-Placebo) during early pain; 2. (Control-Placebo) during late pain |
1. (Placebo-Control) during anticipation |
(Zubieta et al. 2005) |
Placebo analgesia |
PET μOR binding |
Muscle (sustained) |
14 |
N/A |
1. (Placebo-Control) opioid increase; carfentanil binding decrease |
(Koyama et al. 2005) |
Stimulus expectancy |
fMRI |
Thermal |
10 |
1. Decreased pain-induced activation evoked by decreased expectations (expect 48C,actual 50C versus expect 50C,actual 50C) |
N/A |
(Bingel et al. 2006) |
Placebo analgesia |
fMRI |
Laser |
19 |
N/A |
1. (Placebo-Control) during laser stimulation |
(Kong et al. 2006) |
Placebo analgesia |
fMRI |
Thermal |
24 |
N/A |
1. (After-Before placebo treatment)-(Placebo-Control site) |
(Keltner et al. 2006) |
Stimulus expectancy |
fMRI |
Thermal |
27 |
1. High Expectancy,High Temp-Low Expectancy,High temp |
N/A |
(Price et al. 2007) |
Placebo analgesia |
fMRI |
Visceral (Rectal) in patients with irritable bowel syndrome |
9 |
1. Pre-placebo (B1)-Placebo during pain AND Post-placebo (B2)-Placebo; ROIs |
N/A |
(Wager et al. 2007b) |
Placebo analgesia |
PET μOR binding |
Thermal |
15 |
N/A |
1. (Placebo-Control) opioid increase,(Painful-Nonpainful Heat) |
(Craggs et al. 2008) |
Placebo analgesia |
fMRI |
Visceral (Rectal) in patients with irritable bowel syndrome |
9 |
N/A |
1. Placebo-Baseline during pain |
(Eippert et al. 2009a) |
Placebo analgesia |
fMRI |
Thermal |
48 |
1. (Control-Placebo) during early pain; 2. (Control-Placebo) during late pain |
1. (Placebo-Control) early pain; 2. (Placebo-Control) during pain,brainstem-specific |
(Lu et al. 2009) |
Placebo analgesia |
fMRI |
Visceral (Esophageal) |
14 |
1. (Control-Placebo) during pain |
N/A |
(Watson et al. 2009) |
Placebo analgesia |
fMRI |
Laser |
11 |
N/A |
1. (Placebo-Control) during anticipation |
(Kong et al. 2009b) |
Placebo analgesia |
fMRI |
Thermal |
12 |
1. Control > High expectancy in Placebo group |
1. Placebo acupuncture group (N=12),(Pre-Post-placebo) x (Placebo-Control) site |
(Kong et al. 2009a) |
Expectancy effects during treatment |
fMRI |
Thermal |
Different size for each contrast |
1. Verum acupuncture (High-Low expectancy) groups,(Pre-Post-treatment) n = 24; 2. ME of expectancy on high-expectancy site,(pre-post treatment) n = 48 |
1. Verum acup high-expectancy group,(Pre-Post-treatment)-(Expected-Control site) n = 12 |
(Harris et al. 2009) |
Placebo analgesia |
PET μOR binding |
Chronic (fibromyalgia) |
10 |
N/A |
1. Opioid increase (binding decrease) After-Before sham acupuncture |
(Lui et al. 2010) |
Placebo analgesia |
fMRI |
Laser |
31 |
N/A |
1. Placebo/Low exp vs Control/High exp during anticipation; 2. Placebo/Low exp vs Control/High exp during pain |
(Atlas et al. 2010) |
Stimulus expectancy |
fMRI |
Thermal |
18 |
1. Assimilation/Expectancy-induced reductions |
1. Contrast/Expectancy-induced incr |
(Wiech et al. 2010) |
Stimulus expectancy |
fMRI |
Laser |
16 |
1. High > Low threat,across pain and non; 2. Intxn: [Pain,High > Low threat] > [No pain,High > Low threat] |
1. Low > High threat,across pain and non |
(Bingel et al. 2011) |
Expectancy effects during treatment |
fMRI |
Thermal |
22 |
1. Placebo-Nocebo: Decreases |
1. Placebo-Nocebo: Increases |
(Lee et al. 2012) |
Placebo analgesia |
fMRI |
Visceral (Rectal) in patients with irritable bowel syndrome and healthy controls |
17 |
1. Placebo-control during rectal pain: healthy volunteers (decreases); 2. Placebo-control during rectal pain: IBS pts (decreases) |
1. Placebo-control during rectal pain: healthy volunteers (increases); 2. Placebo-control during rectal pain: IBS pts (increases) |
(Geuter et al. 2012) |
Placebo analgesia |
fMRI |
Thermal |
40 |
1. antic: (Control > strong placebo) > (Control > Weak placebo); 2. Early pain: Control > placebo; 3. Late pain: Control > placebo; 4. Late pain: Control > strong placebo; 5. Late pain: Control > weak placebo; 6. Late pain: (Control > strong placebo) > (Control > weak placebo) |
1. antic: Placebo > Control; 2. antic: Strong placebo > Control; 3. antic: Weak placebo > Control; 4. Early pain: placebo > control; 5. Early pain: strong placebo > control; 6. Early pain: weak placebo > control; 7. Early pain: (Strong placebo > control) > (weak placebo > control); 8. Late pain: Weak placebo > control; 9. Late pain: (Strong placebo > Control) > (weak placebo > control) |
(Atlas et al. 2012) |
Expectancy effects during treatment |
fMRI |
Thermal |
21 |
1. Instruction-related decreases; 2. Open-Hidden: Decreases |
1. Instruction-related increases; 2. Open-Hidden: Increases |
(Kong et al. 2013) |
Stimulus expectancy |
fMRI |
Thermal |
46 |
1. For subjs with large exp fx, HC > LC |
1. Low cue > High cue, pain; 2. Low cue > High cue,antic |