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. 2020 Nov 6;3(6):1111–1143. doi: 10.1021/acsptsci.0c00089

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© 2020 American Chemical Society

This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Zone 1 of the domain 2–3 H-bond network in the 2·M_2/up^pro state of 2Q6G. The domain 2–3 linker is guided to M₂ in this network configuration. Glu290 and Asp289 switch to zone 2 in this state.