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(A) Overlay of the m-shaped loop in the dimeric boceprevir-bound CoV-2 Mpro (6WNP, red), monomeric CoV Mpro (2QCY, green), and dimeric CoV Mpro (2BX3, blue). (B) Overlay of the m-shaped loop in the up (blue) and down (yellow) states of crest B. (C) The down state of crest B is generated (red block arrow) by reversibly spooling the more steeply sloped extended form (N- to C-terminal direction denoted by the green arrow) to/from the shallower 310 helical turn.
