Figure 21.
Hypothetical manually generated model of the cis cleavage structure of monomeric Mpro subsequent to turnover, in which the partially unfolded domain 3 of 2QCY projects into the AS (the P1 Gln306 side chain is shown for reference). (A) The modeled C-terminal region (green) extends from domain 3 to the AS. The cognate substrate extracted from 2Q6G (yellow) is overlaid on the modeled structure. The original C-terminal chain in 2QCY is shown in cyan. (B) Same as A, except showing the solvent-accessible surface.