Skip to main content
. 2019 Sep 30;2(1):lqz005. doi: 10.1093/nargab/lqz005

Figure 3.

Figure 3.

(A) The PHOQS HoEBR1 can be arranged into up to four ‘seats’. Greater number of ‘seats’ means smaller loops between units and potentially a gain in structure stability. (B). 1. High-scoring Sequential Allocation (HSA) conformation is based on assigning ‘seats’ sequentially to the highest scoring candidate and known-to-form G4s. Graph. After 10000 iterations of random seat allocation, all 307 candidate conformations of HoEBR1 were found and studied by the mean PQS score of the candidates forming the conformation. In red, blue and green, conformations with 2, 3 and 4 ‘seats’, respectively. 2. Random Allocation High-scoring (RAH) conformation is the highest mean PQS scoring arrangement. (C) Graph. The 307 conformations were normalized by the percentage of the PHOQS that is involved as a PQS to favor shorter loops between subunits and greater ‘seat’ density. 3. The focus was set on the best scoring conformations that present four ‘seats’. These can be occupied by a combination of 10 candidates. 4. Random Allocation normalized High-scoring (RAnH) conformation is the mean normalized highest scoring arrangement. Topologies are not accurate.