Table 1.
Comparison of some of the search engines and analyzers available for use
| QGRS Mapper | G4Hunter | PQSfinder | G4RNA Screener | G4-iM Grinder | |
|---|---|---|---|---|---|
| Format | Web | R script/web | R package | Python script/web | R package |
| Search engine | |||||
| Model | F.R. | S.W. | F.F.R. | S.W. | F.F.R. |
| Run composition | G | G, C | G | G | G, C, T, U, A |
| Run imperfections | N | Y | Y | Y | Y |
| Modulable variables | 5 | 2 | 10 | 3 | 13 |
| Results analysis | |||||
| Structure analysis | Y | Y | Y | Y | Y |
| Structure frequency analysis | N | N | N | N | Y |
| High-order search and analysis | N | N | N | N | Y |
| Structure qualification | N | N | N | N | Y |
| PQS score system | G-Score | G4Hunter | PQSfinder | G4NN (A. N. N.) | Total Score |
| G4Hunter | Frequency | ||||
| cGcC | PQSfinder | ||||
| G4Hunter | |||||
| cGcC |
Structure qualification includes composition analysis and identification of sequences that are already known to form G4 in vitrowithin the results.
Abbreviations: A.N.N.: artificial neural network; F.R.: folding rule; F.F.R.: flexible folding rule; N: no; S.W.: sliding window; Y: yes.