Table 2.
Comparison of gene set functional analysis tools
| GSAn | DAVID | g:Profiler | clusterProfiler | WebGestalt | |
|---|---|---|---|---|---|
| Statistical method | - | Fisher’s Exact | Hypergeometric | Hypergeometric | Hypergeometric |
| Genes id | Symbol | Many | Many | Many | Many |
| Accessibility | WebSite, Rest Api | WebSite, Rest Api, R | WebSite, Rest Api, R | R | WebSite, R |
| Number of organisms | 14* | hundreds | hundreds | 2 | 12* |
| Updates | daily | ||||
| Other resources | No | Yes | Yes | Yes | Yes |
| Reduction step | Synthetic algorithm, see ‘Materials and Methods’ section for more details | Hierarchical filtering of the terms based on the P-value | Score filtering of the terms based on semantic similarity measures | Hierarchical filtering of the terms in the annotation file before computing the analysis |
* Users may contact authors if they need an additional organism to be supported within GSAn.