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. 2020 Mar 20;2(2):lqaa019. doi: 10.1093/nargab/lqaa019

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© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The differences in genome profiles of experimentally validated regulatory lncRNA-gene pairs. (A) The genome sequence, expression, and chromatin accessibility correlation coefficients and genome distance among validated regulatory lncRNA-gene pairs. (B) The number of validated regulatory lncRNA-gene pairs with clear genomic properties, including high-correlation coefficients (>0.7) and closely located (<100 kb). (C) The summary of genomic properties among those validated regulatory lncRNA-gene pairs in terms of correlation and genome distance. (D and E) Examples showing how regulatory lncRNA-gene pairs are correlated in terms of chromatin accessibility: the mouse gene Zfp687 shares the common promoter locus with its nearby divergent lncRNA (D); the promoter region of the mouse gene N2f1 and its nearby divergent lncRNA are co-open (E).