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. 2020 Sep 21;2(3):lqaa066. doi: 10.1093/nargab/lqaa066

Figure 2.

Figure 2.

LDL1/2 and HDA6 regulate lncRNA expression by modulating H3K4me2 and H3Ac levels.(A) X-Y scatter plot and abline of WT-hda6, WT-ldl1/2 and WT-hda6/ldl1/2 showing the expression patterns of the protein-coding gene subset and lncRNAs. (B) Boxplots showing the relative expression of the protein-coding gene subset and lncRNAs in hda6, ldl1/2 and hda6/ldl1/2 compared to those in WT. *P < 0.01, **P < 0.001 (Student's t-test). (C) Metagene ChIP-seq binding profiles of HDA6 and LDL1 in lncRNAs and the protein-coding gene subsets (S1–S3). The profile is from 2 kb upstream of the TSS to 1 kb downstream of the TTS, and the gene lengths were scaled to the same size. (D) Boxplots showing the relative enrichment of H3Ac and H3K4me2 in lncRNAs in hda6, ldl1/2 and hda6/ldl1/2 compared to those in WT. The dotted line indicates the mean value of each group. *P < 0.01, **P < 0.001 (Student's t-test).