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. 2020 Sep 21;2(3):lqaa066. doi: 10.1093/nargab/lqaa066

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© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — The expression of H3Ac and H3K4me2 in HDA6/LDL1-targeted lncRNAs is increased in hda6/ldl1/2 compared to WT. (A) A Venn diagram showing statistically significant overlap between lncRNAs targeted by HDA6 and those targeted by LDL1 (208 lncRNAs; P < 4e -87, hypergeometric test). (B) Metagene ChIP-seq binding profiles of HDA6 and LDL1 in HDA6-targeted lncRNAs, LDL1-targeted lncRNAs, HDA6/LDL1-cotargeted lncRNAs and lncRNAs not targeted by HDA6 or LDL1. The profile is from 2 kb upstream of the TSS to 1 kb downstream of the TTS, and the gene lengths were scaled to the same size. (C) Violin plots with boxplots showing the relative expression on the HDA6/LDL1-cotargeted and nontargeted lncRNAs in hda6/ldl1/2 compared to those in WT. **P < 0.001 (Student's t-test). (D) Boxplots showing the relative enrichment of H3Ac and H3K4me2 in the HDA6/LDL1-cotargeted and non-targeted lncRNAs in hda6/ldl1/2 compared to those in WT. The dotted line indicates the mean value of each group. **P < 0.001 (Student's t-test).