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. 2020 Sep 21;2(3):lqaa066. doi: 10.1093/nargab/lqaa066

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© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — The expression of lncRNAs that are nonexpressed or show low expression is associated with H3Ac/H3K4me2 changes regulated by the HDA6-LDL1/2 histone modification complex. The HDA6-LDL1/2 histone modification complex can bind to the promoter region or gene body of lncRNAs that are non-expressed or show low expression to suppress their expression by histone deacetylation and H3K4 demethylation. The expression of protein-coding genes may be positively or negatively regulated by their neighboring lncRNAs; therefore, HDA6-LDL1/2 may affect the expression of protein-coding genes by regulating neighboring lncRNAs.