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Estimation of mouse ratio in human–mouse mixtures. (A) Accurate estimation of mouse ratio by the deep NGS sequencing in a serial dilution of human–mouse DNA mixtures with mouse ratios of 90%, 80%, 70%, 50%, 30%, 20%, 10%, 7%, 5% and 0%. (B, C) Mouse ratios estimated in 220 PDX and 31 PDXO models by three approaches, assayed on the same sample for each model. (D) A quadratic relationship between mouse ratios estimated by the deep NGS sequencing and WES in 220 PDX models.
