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. 2020 Aug 6;2(3):lqaa054. doi: 10.1093/nargab/lqaa054

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© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Liftover preserves DMRs. (A) Distribution of delta values of CpGs among 43 WGBS samples. (B) The percentage of overlapping CpGs with delta ≥ 0.20 among 43 samples. (C) Enrichment analysis of CpGs with delta ≥ 0.20 across 43 samples. (D) Jaccard statistic and overlapping proportion between DMR1 (liftover-LNCaP versus liftover-PrEC) and DMR2 (alignment-LNCaP versus alignment-PrEC) in hg38. (E) DMC sites between a pair of liftover and alignment output in 43 samples called by MethPipe, in comparison with DMCs between LNCaP and PrEC. (F) DMRs between a pair of liftover and alignment output in 43 samples called by MethPipe, in comparison with DMRs of alignment-LNCaP versus alignment-PrEC in hg38.