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. 2020 Oct 9;2(4):lqaa082. doi: 10.1093/nargab/lqaa082

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© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Putative and rare cell type discovery in the 1.3 million neural cell dataset. (A) t-SNE visualization of the AIDE embedding on 5% sampled data from the full dataset. Data are sampled based on the 64 clusters obtained from scAIDE. Colors represent the 19 cell type annotations from our biological analysis. (B) t-SNE visualization on cells annotated with the label: neural stem/precursor cells. These correspond to the orange cells in the same position as in A. Annotations were validated by different markers and their respective positioning. NPC: neural progenitor cells; aNSC: activated neural stem cells; OPC: oligodendrocyte progenitor cells. (C) Top significantly expressed marker genes in each respective cell types.