Figure 1.
Differential expression of miRNAs in THP-1 cells infected with clinical isolated Mycobacterium tuberculosis strains
Expression levels of the above six miRNAs were analyzed by qRT-PCR in THP-1 cells infected with Mycobacterium tuberculosis strains, isolated from 120 clinical sputum samples, respectively. The data showed that the expression levels of the six miRNAs (miR-155, miR-29b-1*, miR-150, miR-146a, miR-212 and miR-483-5p) were up-regulated, which was consistent with the above finding. In addition, the up-regulated multiple of miR-155 was higher than other 5 miRNAs (all P-values were <0.01). Thus, miR-155 was selected as the diagnostic target for further study