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Painting contact patterns for intra- and interdomain interactions (A), loop interactions (B) and heterogeneous connectivity along the polymer backbone (C). (Upper) Designed interactions in the polymer network model. (Lower) Converted contact matrix, with a snapshot of polymer conformations in the polymer dynamics simulation (Supplementary Videos S1–S3). (C) TAD-like domains are highlighted by dashed lines. (Right) Removal of a domain-boundary part (yellow) results in domain fusion.
