Table 2.
Clinical and Biochemical Characteristics of the Study Subjects According to the Tertiles of Asprosin
| Characteristics | Lower Tertile (n=69) | Middle Tertile (n=69) | Upper Tertile (n=69) | P value |
|---|---|---|---|---|
| Age, y | 62.99 ± 10.94 | 59.83 ± 10.95 | 61.84 ± 10.19 | 0.216 |
| Sex, male (%) | 42(60.9%) | 34(49.3%) | 44(63.8%) | 0.189 |
| DM duration, mouth | 96.00(12.00–168.00) | 96.00(14.50–168.00) | 120.00(54.00, 186.00) *† | 0.006 |
| Smoking, n (%) | 14(20.3%) | 15(21.7%) | 24(34.8%) | 0.099 |
| BMI | 24.09 ± 3.47 | 24.42 ± 3.22 | 25.43 ± 3.45 * | 0.008 |
| WHR | 0.93 ± 0.07 | 0.93 ± 0.05 | 0.93 ± 0.06 | 0.682 |
| SBP (mmHg) | 132.86 ± 15.27 | 133.07 ± 16.33 | 137.07 ± 16.14 | 0.218 |
| DBP (mmHg) | 78.13 ± 7.76 | 79.35 ± 7.86 | 82.62 ± 9.08 *† | 0.005 |
| Hypertension, n (%) | 37(53.6%) | 44(63.8%) | 53(76.8%) * | 0.017 |
| ACEI or ARB use | 19(27.5%) | 16(23.2%) | 26(37.7%) | 0.159 |
| Statins use | 24(34.8%) | 17(24.6%) | 19(27.5%) | 0.400 |
| Only diet and exercise | 4(5.8%) | 2(2.9%) | 3(4.3%) | 0.706 |
| Insulin | 47(68.1%) | 41(59.4%) | 51(73.9%) | 0.189 |
| Oral agents | 44(63.8%) | 55(79.7%) | 48(69.6%) | 0.113 |
| HbA1c (%) | 8.92 ± 2.06 | 8.81 ± 1.88 | 8.78 ± 1.88 | 0.541 |
| FPG (mmol/L) | 9.34 ± 3.76 | 9.70 ± 3.36 | 9.56 ± 3.58 | 0.634 |
| 2hPG(mmol/L) | 17.57 ± 5.55 | 17.21 ± 5.61 | 17.11 ± 5.60 | 0.776 |
| FIns (µIU/mL) | 6.56(4.24–12.51) | 6.71(4.04–11.52) | 10.14(5.6–18.70) *† | 0.008 |
| FC-P (ng/mL) | 1.58(1.05–1.97) | 1.80(1.23–2.29) * | 1.90(1.19–2.38) * | 0.027 |
| HOMA-IR | 2.95(1.42–4.50) | 2.70(1.58–4.40) | 3.78(2.39–6.77) *† | 0.006 |
| Uric acid (μmol/L) | 272.15 ± 89.53 | 278.96 ± 86.45 | 311.25 ± 81.69 * | 0.005 |
| TC (mmol/L) | 4.53 ± 1.06 | 4.55 ± 1.09 | 4.84 ± 1.11 | 0.176 |
| TG (mmol/L) | 1.31(0.94–1.81) | 1.52(1.20–2.03) | 1.69(1.17–2.45) * | 0.016 |
| HDL-C (mmol/L) | 1.00(0.85–1.27) | 1.00(0.83–1.27) | 0.99(0.84–1.17) | 0.165 |
| LDL-C (mmol/L) | 2.37 ± 0.76 | 2.53 ± 0.87 | 2.64 ± 0.86 | 0.792 |
| Apoprotein A (g/L) | 1.18 ± 0.27 | 1.16 ± 0.24 | 1.13 ± 0.23 | 0.450 |
| Apoprotein B (g/L) | 0.95 ± 0.29 | 0.92 ± 0.28 | 1.00 ± 0.35 | 0.258 |
| Creatinine (μmol/L) | 60.90(50.15–74.45) | 61.70(51.00–77.95) | 67.20(54.35–82.30) | 0.150 |
| BUN (mmol/L) | 5.42(4.45–6.69) | 5.28(4.65–6.59) | 6.07(4.84–7.24) | 0.113 |
| UACR (mg/g) | 21.33(12.17–35.62) | 21.71(12.31–53.89) | 50.78(26.25–117.26) *† | <0.001 |
| UACR≥30mg/g, n (%) | 21(30.43%) | 30(43.48%) | 49(71.01%) *† | <0.001 |
| eGFR(mL/[min1.73m2]) | 115.06 ± 36.15 | 106.12 ± 35.86 | 105.70 ± 35.95 | 0.228 |
Notes: *Significant P ≤0.05 vs group of lower tertile. †Significant P ≤0.05 vs group of middle tertile.