Figure 1. Novel capsaicin analogs for the study of TRPV1 ligand-binding pocket.

(A–C) Characteristics of the ligand-binding pocket with distinct vanilloid binding poses. (D) Distance between the two capsaicin hydrogen bonding residues T551 and E571 in the apo state (blue, PDB: 3J5P) and the capsaicin-bound state (brown, PDB: 3J5R). (E) Molecular structure of capsaicin and its analogs, with differences in the neck highlighted in red. A rough scale bar is shown to the left.