Author response image 1. of CaM⁺²Ca, CaMAC⁺²Ca, and CaMPDE⁺²Ca, were represented as multi step reactions with rates in the table given below.

The system still exhibits in-phase and out-of-phase qualitative responses, with an additional 3 parameters. Since additional parameters did not affect outcome, we retained the Michaelis-Menten formulation.