Figure 4.

Central retina rod neuroprotection is possible in dark-reared Pde6brd10 mice. (A) At P50, central rod protection (averaged from inferior and superior retina) was observed in female (and not male) Pde6brd10 mice given approximately 80 mg/kg Norgestrel + 5 mg/kg/day MB (N5MB) diet. Other groups are: untreated mice, approximately 1 mg/kg/day MB (1MB), approximately 5 mg/kg/day MB (5MB), approximately 80 mg/kg/day Norgestrel (N). (B) Further analysis finds that the difference between mice fed normal chow versus N5MB chow was significant between male and female P50 dark-reared Pde6brd10 mice (horizontal line); in male mice this difference was not statistically distinguishable from zero, whereas it was in female mice (star). Together, these results show that the greatest impact on rod survival by N5MB chow is found in P50 dark-reared female Pde6brd10 mice.