TABLE 1.
Descriptive Analysis
| Age in years (median and range) | 60.2 (54.2–66.3) |
| Gender (n = 29), n (%) | |
| Male | 13 (44.8) |
| Female | 16 (55.2) |
| Sequential Organ Failure Assessment score (interquartile range) | 9.5 (5.0–14.0) |
| Source of sepsis (n = 29), n (%) | |
| Pneumonia | 21 (72) |
| Hepatobiliary | 4 (14) |
| Urinary tract infection | 2 (7) |
| Enterocolitis | 2 (7) |
| Type of interventions tested (n = 145), n (%) | |
| Medication effect | 73 (50.3) |
| Noninvasive and mechanical ventilation | 26 (17.9) |
| IV fluids | 23 (15.9) |
| No intervention | 9 (6.4) |
| Hemodialysis | 8 (5.5) |
| Blood product transfusion | 4 (2.7) |
| Source control | 2 (1.4) |
| Outcomes studied (n = 145) | |
| Fluid hemostasis | 33 (22.7) |
| Respiratory effects | 28 (19.3) |
| Cardiovascular effects | 24 (16.5) |
| Neurologic effects | 16 (11.0) |
| Metabolic effects (including renal) | 14 (9.6) |
| Model calibration checks | 9 (6.2) |
| Inflammatory (sepsis homeostasis) | 18 (12.4) |
| Transfusion effects | 3 (2.1) |