FIGURE 2.

Expression of the most deregulated miRNAs in GBM and their influence on proliferation, angiogenesis, invasion, migration, and apoptosis of GBM. miRNAs, frequently carried by EVs, act as epigenetic modulators and regulate several key processes in GBM. The deregulation of any of these miRNAs generates abnormal gene expression which leads to disease progression. Black – miRNAs with unknown regulation in GBM; green – miRNAs upregulated in GBM; red – miRNAs downregulated in GBM. Green circles show miRNAs positive effect on described processes; red circles show miRNAs negative effect on described processes.