FIGURE 3.

Expression in AD and PD of the most deregulated miRNAs in GBM. AD is characterized by the deposition of Aβ fibrils in the brain parenchyma and vessel walls and by the accumulation of aberrant phosphorylated Tau protein in neurons. PD is an α-synucleinopathy characterized by the formation of Lewy bodies by the accumulation of α-synuclein predominantly in neurons, causing the loss of dopaminergic neurons. In both diseases, abnormal regulation of miRNAs plays a key role in the onset and progression of the diseases. Black – miRNAs with unknown regulation in AD and PD; green – miRNAs upregulated in AD and PD; red – miRNAs downregulated in AD and PD.