Table 3.
Clinical trials using MSCs to treat neonatal diseases recorded in ClinicalTrials.gov.
| ClinicalTrials.gov identifier | Cell source | Route of administration | Age eligibility | Disease | Phase | No. of patient | Country |
|---|---|---|---|---|---|---|---|
| NCT03356821 | BMSCs | Intranasal | newborns with gestational age ≥36 weeks | PAIS | I/II | 10 | Netherlands |
| NCT04255147 | UC-MSCs | Intravenous | up to 21-day old | BPD | I | 9 | Canada |
| NCT03683953 | MSCs | Intrathecal | newborns with gestational age between 28 and 37 weeks | BPD | I | 200 | China |
| NCT03601416 | UC-MSCs | Intravenous | up to 1-year old | BPD | II | 57 | China |
| NCT03645525 | UC-MSCs | Intratracheal | up to 3-week old | BPD | I/II | 180 | China |
| NCT03774537 | UC-MSCs | Intravenous | up to 14-day old | BPD | I/II | 20 | China |
| NCT01207869 | UC-MSCs | Intrathecal | up to 6-month old | BPD | I | 10 | China |
| NCT03631420 | UC-MSCs | – | 36 to 48-week old | BPD | I | 9 | Taiwan |
| NCT03857841 | BMSCs-EVs (UNEX-42) | Intravenous | up to 14-day old | BPD | I | 18 | United States |
| NCT02443961 | MSCs | – | 1-month to 28-week old | BPD | I | 10 | Spain |
| NCT04062136 | UC-MSCs | Intravenous | 1 to 6-month old | BPD | I | 10 | Vietnam |
| NCT03873506 | UC-MSCs | Intravenous | 1-month to 5-year old | BPD | I | 30 | China |
| NCT03558334 | UC-MSCs | Intravenous | all ages | BPD | I | 12 | China |
| NCT03392467 | UCB-MSCs (Pneumostem®) | – | up to 13-day old | BPD | II | 60 | Korea |
| NCT04003857 | UCB-MSCs (Pneumostem®) | Intratracheal | 6 to 60-month old | BPD | follow-up of NCT03392467 | 60 | South Korea |
| NCT01828957 | UCB-MSCs (Pneumostem®) | Intratracheal | up to 14-day old | BPD | II | 69 | South Korea |
| NCT01897987 | UCB-MSCs (Pneumostem®) | Intratracheal | 7-month old | BPD | follow-up of NCT01828957 | 70 | South Korea |
| NCT02023788 | UCB-MSCs (Pneumostem®) | Intratracheal | 45 to 63-month old | BPD | follow-up of NCT01632475 | 8 | South Korea |
| NCT03378063 | UCB-MSCs | – | 1 to 3-month old | BPD | I | 100 | China |
| NCT03635450 | UC-MSCs | Intravenous | up to 48-hour old | HIE | I | 6 | United States |
| NCT02854579 | a. hFF-NPCs b. MSCs-derived paracrine factors c. hFF-NPCs + MSCs-derived paracrine factors |
Intrathecal | up to 14-day old | HIE | – | 120 | China |
| NCT01962233 | UC-MSCs | Intravenous | all ages | HIE | I | 10 | China |
| NCT03525418 | BMSCs | Intramyocardial | up to 1-year old | HLHS | I/II | 30 | United States |
| NCT03079401 | MPCs | Intramyocardial | up to 5-year old | HLHS | I/II | 24 | United States |
| NCT03525418 | BMSCs | Intramyocardial | up to 1-year old | HLHS | I/II | 30 | United States |
| NCT02855112 | ADSCs | Intrathecal | 5 to 12-month old | ISMA | I/II | 10 | Iran |
| NCT02274428 | UCB-MSCs (Pneumostem®) | Intraventricular | 23 to 34-week gestational age | IVH | I/II | 9 | South Korea |
| NCT02673788 | UCB-MSCs (Pneumostem®) | – | 6-month to 2-year old | IVH | follow-up of NCT02274428 | 9 | South Korea |
| NCT02890953 | UCB-MSCs (Pneumostem®) | Intraventricular | within 28 postnatal days | IVH | IIa | 22 | South Korea |
ADSCs, adipose tissue-derived mesenchymal stromal cells; BPD, bronchopulmonary dysplasia; BMSCs, bone marrow-derived mesenchymal stromal cells; CP, cerebral palsy; CM, conditioned medium; EVs, extracellular vesicles; hFF-NPCs, aborted human fetal forebrain-derived neural progenitor cells; HIE, hypoxic-ischemic encephalopathy; HLHS, hypoplastic left heart syndrome; UCB-MSCs, umbilical cord blood-derived mesenchymal stromal cells; UC-MSCs, umbilical cord-derived mesenchymal stromal cells; ISMA, infantile spinal muscular atrophy; IVH, intraventricular hemorrhage; MPC, mesenchymal precursor cells; PAIS, perinatal arterial ischemic stroke; UC-HSCs umbilical cord-derived hematopoietic stem cells; uAVC, unbalanced atrioventricular canal.