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. 2020 Nov 17;10:19985. doi: 10.1038/s41598-020-77118-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Parameters of the elevated plus-maze. (a) Time spent (in seconds) in the open arms by SAL and CRF offspring. (b) Number of entries into the open arms by SAL and CRF offspring. (c) Number of stretching behaviour by SAL and CRF offspring. (d) Time spent (in seconds) in the open arms by CT and LB offspring. (e) Number of entries into the open arms by CT and LB offspring. (f) Number of stretching behaviour by CT and LB offspring. Results are presented as means SEM. Two-way ANOVA, interaction-effect, where CRF males increased their time while CRF females decreased. *p < 0.05, 2-way ANOVA, treatment-effect. n = 10–12 animals per group. SAL, offspring of saline-infused dams; CRF, offspring of corticotropin-releasing factor-infused dams; CT, offspring of control dams; LB, offspring of stressed dams.